王大毛

王大毛，教授，重庆市引进高层次人才，国家“三区”科技人才，重庆市科技特派员

教育经历

2003.9-2007.7 西北农林科技大学， 食品科学与工程， 本科

2007.9-2010.6 西北农林科技大学， 粮食油脂及植物蛋白质工程， 硕士

2012.3-2016.8 高丽大学（韩国）， 食品生物技术， 博士

工作经历

2010.7-2011.2 上海润盈生物工程有限公司， 研发经理

2016.8-2018.8 瑞典皇家理工学院，化学，生物技术与健康学院，博士后

2018.9-2019.8 瑞典皇家理工学院，化学，生物技术与健康学院，特聘研究员

2017.6-2017.10 斯德哥尔摩大学，材料学院， 访问学者（兼）

学术情况概述

研究方向主要包括碳水化合物酶工程，多糖高效降解技术，功能性寡糖制备技术，生物质精炼技术，农作物副产物高值转化等。获中国，韩国，美国发明专利多项。主持国家自然科学基金面上项目，重庆市自然科学基金面上项目，瑞典瓦伦堡木材科学中心项目等多项。担任Frontiers in Chemistry编委， Journal of Integrative Agriculture 青年编委，国家自然科学基金评审专家，食品科学及生物技术领域多种权威SCI期刊的审稿人。

近五年发表论文

1. Guo, Qing, Meiling Dan, Yuting Zheng, Ji Shen, Guohua Zhao, and Damao Wang*. "Improving the thermostability of a novel PL-6 family alginate lyase by rational design engineering for industrial preparation of alginate oligosaccharides." International Journal of Biological Macromolecules 249 (2023): 125998.

2. Yanping Li, Meiling Dan, Ji Shen, Guohua Zhao, Yujie Wang, Damao Wang*,

“Efficient production of chito-oligosaccharides through microwave-assisted hydrothermal and low-acid-mediated degradation and deacetylation of chitin” LWT, 186 (2023),115230

3. Shen, Ji, Meiling Dan, Yanping Li, Xiaoqi Tao, Guohua Zhao, and Damao Wang*. "Controllable and complete conversion of agarose into oligosaccharides and monosaccharides by microwave-assisted hydrothermal and enzymatic hydrolysis and antibacterial activity of agaro-oligosaccharides." International Journal of Biological Macromolecules (2023): 126319.

4. Dan, Meiling, Yuting Zheng, Guohua Zhao, Yves SY Hsieh, and Damao Wang*. "Current insights of factors interfering the stability of lytic polysaccharide monooxygenases." Biotechnology Advances (2023): 108216.

5. Zhou, Zhenjiang, Sheng Li, Yiyuan Zou, Lin Lei, Yun Zhou, Damao Wang, Fayin Ye, and Guohua Zhao. "Coating peanut shell lignin nanospheres with gelatin via non-covalent adsorption: Key parameters, consequences, and underlying interactions." International Journal of Biological Macromolecules 233 (2023): 123607.

6. Hsiung, Shih-Yi, Jing Li, Balazs Imre, Mu-Rong Kao, Hsien-Chun Liao, Damao Wang, Chih-Hui Chen, Pi-Hui Liang, Philip J. Harris, and Yves SY Hsieh. "Structures of the xyloglucans in the monocotyledon family Araceae (aroids)." Planta 257, no. 2 (2023): 39.

7. Wei, Guozheng, Meiling Dan, Guohua Zhao, and Damao Wang*. "Recent advances in chromatography-mass spectrometry and electronic nose technology in food flavor analysis and detection." Food Chemistry 405 (2023): 134814.

8. Li, Jing, Shih-Yi Hsiung, Mu-Rong Kao, Xiaohui Xing, Shu-Chieh Chang, Damao Wang, Pei-Yun Hsieh et al. "Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce." Carbohydrate Research 521 (2022): 108662.

9. Zheng, Yuting, Yujie Wang, Meiling Dan, Yanping Li, Guohua Zhao, and Damao Wang*. "Characterization of degradation patterns and enzymatic properties of a novel alkali-resistant alginate lyase AlyRm1 from Rubrivirga marina." Current Research in Food Science 6 (2023): 100414.

10. Dan, Meiling, Ji Shen, Guohua Zhao, and Damao Wang*. "Complete conversion of agarose into water soluble agaro-oligosaccharides by microwave assisted hydrothermal hydrolysis." Food Chemistry 395 (2022): 133622.

11. Wang, Damao, Mu-Rong Kao, Jing Li, Peicheng Sun, Qijun Meng, Anisha Vyas, Pi-Hui Liang, Yane-Shih Wang, and Yves SY Hsieh. "Novel Two-Step Process in Cellulose Depolymerization: Hematite-Mediated Photocatalysis by Lytic Polysaccharide Monooxygenase and Fenton Reaction." Journal of Agricultural and Food Chemistry 70, no. 32 (2022): 9941-9947.

12. Zheng, Yuting, Yanping Li, Yuanyuan Yang, Ye Zhang, Di Wang, Peiyao Wang, Ann CY Wong, Yves SY Hsieh, and Damao Wang*. "Recent advances in bioutilization of marine macroalgae carbohydrates: Degradation, metabolism, and fermentation." Journal of Agricultural and Food Chemistry 70, no. 5 (2022): 1438-1453.

13. Peiyao Wang, Yuting Zheng, Yanping Li, Ji Shen, Meiling Dan, Damao Wang*,

Recent advances in biotransformation, extraction and green production of D-mannose,

Current Research in Food Science, Volume 5, 2022

14. Li, Yanping, Yuting Zheng, Ye Zhang, Yuanyuan Yang, Peiyao Wang, Balázs Imre, Ann CY Wong, Yves SY Hsieh, and Damao Wang*. "Brown algae carbohydrates: Structures, pharmaceutical properties, and research challenges." Marine Drugs 19, no. 11 (2021): 620.

15. He, Yonglin, Fayin Ye, Sheng Li, Damao Wang, Jia Chen, and Guohua Zhao. "Effect of sand-frying-triggered puffing on the multi-scale structure and physicochemical properties of cassava starch in dry gel." Biomolecules 11, no. 12 (2021): 1872.

16. Li, Jing, Damao Wang, Shu-Chieh Chang, Pi-Hui Liang, Vaibhav Srivastava, Shih-Yun Guu, Jiun-Jie Shie, Kay-Hooi Khoo, Vincent Bulone, and Yves SY Hsieh. "Production of structurally defined chito-oligosaccharides with a single N-acetylation at their reducing end using a newly discovered chitinase from Paenibacillus pabuli." Journal of Agricultural and Food Chemistry 69, no. 11 (2021): 3371-3379.

17. Wang, Damao*, Yanping Li, Yuting Zheng, and Yves SY Hsieh. "Recent advances in screening methods for the functional investigation of lytic polysaccharide monooxygenases." Frontiers in Chemistry 9 (2021): 653754. 

18. Wang, Yulin, Jia Chen, Damao Wang, Fayin Ye, Yonglin He, Zicong Hu, and Guohua Zhao. "A systematic review on the composition, storage, processing of bamboo shoots: Focusing the nutritional and functional benefits." Journal of Functional Foods 71 (2020): 104015.

19. Li, Jing, Damao Wang, Xiaohui Xing, Ting-Jen Rachel Cheng, Pi-Hui Liang, Vincent Bulone, Jeong Hill Park, and Yves SY Hsieh. "Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc." International journal of biological macromolecules 135 (2019): 29-37.

20. Wang, Damao, Jing Li, Ann CY Wong, Finn L. Aachmann, and Yves SY Hsieh. "A colorimetric assay to rapidly determine the activities of lytic polysaccharide monooxygenases." Biotechnology for Biofuels 11, no. 1 (2018): 1-11.

21. Wang, Damao, Olav A. Aarstad, Jing Li, Lauren S. McKee, Gerd Inger Sætrom, Anisha Vyas, Vaibhav Srivastava, Finn L. Aachmann, Vincent Bulone, and Yves SY Hsieh. "Preparation of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) and guluronic acid rich alginate using a unique exo-alginate lyase from Thalassotalea crassostreae." Journal of agricultural and food chemistry 66, no. 6 (2018): 1435-1443.

22. Wang, Damao, Jing Li, G. Salazar-Alvarez, L. S. McKee, V. Srivastava, J. A. Sellberg, V. Bulone, and Y. S. Y. Hsieh. "Production of functionalised chitins assisted by fungal Lytic Polysaccharide Monooxygenase." Green Chemistry 20, no. 9 (2018): 2091-2100.

授权专利

Novel beta-1,3-1,6-endoglucanase for producing oligosacchairdes and glucose from beta-glucan, 韩国专利, 2017, 10-1804050

Novel beta-1,6-endoglucanase for producing gentiobiose and glucose from beta-glucan, 韩国专利, 2017, 10-1784665

Novel beta-1,3-1,6-endoglucanase producing, from beta-glucan, oligosaccharides or glucose. US 2020/0002738 A1, 美国专利

由beta-葡聚糖中产生龙胆二糖或葡萄糖的新型beta-1,6-内切葡聚糖酶. 中国专利，201780042236.3

科研项目

开发新型多糖单加氧酶用于木材细胞壁降解. 瑞典瓦伦堡木材科学中心项目， 2016-2018，主持

海洋生物质的生物精炼技术开发. 欧盟ERA-NET项目，2016-2019，参与

海洋多糖生物质的生物转化与功能化，西南大学引进人才启动项目，2020-2023，主持

新型海藻酸裂解酶催化机制及海藻寡糖工业酶催化剂开发，重庆市留学回国人员创新创业项目，2020-2021, 主持

红藻来源添加代糖3.6脱水L半乳糖的高效绿色制备，益生菌发酵纯化及健康评价研究，广西农产资源化学与生物技术重点实验室开放课题，2021-2023, 主持

高耐热褐藻多糖裂解酶结构与催化机制解析及定向进化, 重庆市自然科学基金面上项目, 2020-2023, 主持

组氨酸甲基化及氧化铁光催化对甲壳素多糖单加氧酶的催化机制研究，国家自然科学基金面上项目，2022-2025，主持

啤酒工业中副产物的高值转化利用技术研究，宜宾研究院重点研发项目，2023-2025，主持

重庆市留学回国人员创新创业重点项目，2023-2025，主持

学术活动（部分）

2019亚洲生物技术研讨会（ACB2019，台北），大会演讲

2018斯德哥尔摩细胞壁学会，大会演讲，学术评委

2017斯德哥尔摩细胞壁学会，大会演讲，学术评委

2016第十一届世界代谢工程学会（神户），大会报告

2016韩国代谢组学学会（首尔），大会演讲

2015第37 届世界生物技术与能源学会（圣迭戈） 大会报告

联系方式

西南大学食品科学学院

重庆市北碚区天生路2号

邮政编码：400715

E-mail: wangdamao@swu.edu.cn

学术主页：https://www.researchgate.net/profile/Damao_Wang

课题组近年来多次指导学生获得国家级大学生创新项目，研究生创新项目，团队氛围活泼融洽，课余活动丰富多彩。欢迎对食品生物技术，酶工程，生物资源利用等领域感兴趣的同学加入实验室！